TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers

OBJECTIVES: To determine whether TMEM106B single nucleotide polymorphisms (SNPs) are associated with frontotemporal lobar degeneration (FTLD) in patients with and without mutations in progranulin (GRN) and to determine whether TMEM106B modulates GRN expression. METHODS: We performed a case-control s...

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Hlavní autoři: Finch, N., Carrasquillo, M.M., Baker, M., Rutherford, N.J., Coppola, G., DeJesus-Hernandez, M., Crook, R., Hunter, T., Ghidoni, R., Benussi, L., Crook, J., Finger, E., Hantanpaa, K.J., Karydas, A.M., Sengdy, P., Gonzalez, J., Seeley, W.W., Johnson, N., Beach, T.G., Mesulam, M., Forloni, G., Kertesz, A., Knopman, D.S., Uitti, R., White, C.L., Caselli, R., Lippa, C., Bigio, E.H., Wszolek, Z.K., Binetti, G., Mackenzie, I.R., Miller, B.L., Boeve, B.F., Younkin, S.G., Dickson, D.W., Petersen, R.C., Graff-Radford, N.R., Geschwind, D.H., Rademakers, R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034409/
https://ncbi.nlm.nih.gov/pubmed/21178100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e31820a0e3b
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