FTLD-TDP With and Without GRN Mutations Cause Different Patterns of CA1 Pathology

Heterozygous loss-of-function mutations in the GRN gene lead to progranulin (PGRN) haploinsufficiency and cause frontotemporal lobar degeneration with TDP-43 pathology type A (FTLD-TDP type A). PGRN is a highly conserved, secreted glycoprotein and functions in the central nervous system as a key mod...

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Détails bibliographiques
Publié dans:J Neuropathol Exp Neurol
Auteurs principaux: Mao, Qinwen, Zheng, Xiaojing, Gefen, Tamar, Rogalski, Emily, Spencer, Callen L, Rademakers, Rosa, Fought, Angela J, Kohler, Missia, Weintraub, Sandra, Xia, Haibin, Mesulam, Marek-Marsel, Bigio, Eileen H
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7967835/
https://ncbi.nlm.nih.gov/pubmed/31361008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnen/nlz059
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