TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers

OBJECTIVES: To determine whether TMEM106B single nucleotide polymorphisms (SNPs) are associated with frontotemporal lobar degeneration (FTLD) in patients with and without mutations in progranulin (GRN) and to determine whether TMEM106B modulates GRN expression. METHODS: We performed a case-control s...

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Main Authors: Finch, N., Carrasquillo, M.M., Baker, M., Rutherford, N.J., Coppola, G., DeJesus-Hernandez, M., Crook, R., Hunter, T., Ghidoni, R., Benussi, L., Crook, J., Finger, E., Hantanpaa, K.J., Karydas, A.M., Sengdy, P., Gonzalez, J., Seeley, W.W., Johnson, N., Beach, T.G., Mesulam, M., Forloni, G., Kertesz, A., Knopman, D.S., Uitti, R., White, C.L., Caselli, R., Lippa, C., Bigio, E.H., Wszolek, Z.K., Binetti, G., Mackenzie, I.R., Miller, B.L., Boeve, B.F., Younkin, S.G., Dickson, D.W., Petersen, R.C., Graff-Radford, N.R., Geschwind, D.H., Rademakers, R.
Formato: Artigo
Idioma:Inglês
Publicado: Lippincott Williams & Wilkins 2011
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034409/
https://ncbi.nlm.nih.gov/pubmed/21178100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e31820a0e3b
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