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Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice

Single nucleotide polymorphisms (SNPs) in TMEM106B encoding the lysosomal type II transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) of GRN (progranulin gene) mutation carriers. Currently, it is unclear if progranulin (PGRN) and TMEM106B are synergistically lin...

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書目詳細資料
發表在:EMBO Rep
Main Authors: Werner, Georg, Damme, Markus, Schludi, Martin, Gnörich, Johannes, Wind, Karin, Fellerer, Katrin, Wefers, Benedikt, Wurst, Wolfgang, Edbauer, Dieter, Brendel, Matthias, Haass, Christian, Capell, Anja
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534633/
https://ncbi.nlm.nih.gov/pubmed/32929860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050241
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