Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

Loss-of-function mutations in progranulin (GRN) and a non-coding (GGGGCC)(n) hexanucleotide repeat expansions in C9ORF72 are the two most common genetic causes of frontotemporal lobar degeneration with aggregates of TAR DNA binding protein 43 (FTLD-TDP). TMEM106B encodes a type II transmembrane prot...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Nicholson, Alexandra M., Zhou, Xiaolai, Perkerson, Ralph B., Parsons, Tammee M., Chew, Jeannie, Brooks, Mieu, DeJesus-Hernandez, Mariely, Finch, NiCole A., Matchett, Billie J., Kurti, Aishe, Jansen-West, Karen R., Perkerson, Emilie, Daughrity, Lillian, Castanedes-Casey, Monica, Rousseau, Linda, Phillips, Virginia, Hu, Fenghua, Gendron, Tania F., Murray, Melissa E., Dickson, Dennis W., Fryer, John D., Petrucelli, Leonard, Rademakers, Rosa
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984311/
https://ncbi.nlm.nih.gov/pubmed/29855382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0545-x
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