Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

Frontotemporal dementia (FTD)-causing mutations in the CHMP2B gene lead to the generation of mutant C-terminally truncated CHMP2B. We report that transgenic mice expressing endogenous levels of mutant CHMP2B developed late-onset brain volume loss associated with frank neuronal loss and FTD-like chan...

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Bibliografiset tiedot
Julkaisussa:Hum Mol Genet
Päätekijät: Clayton, Emma L., Mancuso, Renzo, Nielsen, Troels Tolstrup, Mizielinska, Sarah, Holmes, Holly, Powell, Nicholas, Norona, Frances, Larsen, Jytte Overgaard, Milioto, Carmelo, Wilson, Katherine M., Lythgoe, Mark F., Ourselin, Sebastian, Nielsen, Jörgen E., Johannsen, Peter, Holm, Ida, Collinge, John, Oliver, Peter L., Gomez-Nicola, Diego, Isaacs, Adrian M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2017
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409096/
https://ncbi.nlm.nih.gov/pubmed/28093491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx003
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