Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

Frontotemporal dementia (FTD)-causing mutations in the CHMP2B gene lead to the generation of mutant C-terminally truncated CHMP2B. We report that transgenic mice expressing endogenous levels of mutant CHMP2B developed late-onset brain volume loss associated with frank neuronal loss and FTD-like chan...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Hum Mol Genet
Hlavní autoři: Clayton, Emma L., Mancuso, Renzo, Nielsen, Troels Tolstrup, Mizielinska, Sarah, Holmes, Holly, Powell, Nicholas, Norona, Frances, Larsen, Jytte Overgaard, Milioto, Carmelo, Wilson, Katherine M., Lythgoe, Mark F., Ourselin, Sebastian, Nielsen, Jörgen E., Johannsen, Peter, Holm, Ida, Collinge, John, Oliver, Peter L., Gomez-Nicola, Diego, Isaacs, Adrian M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409096/
https://ncbi.nlm.nih.gov/pubmed/28093491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx003
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky