Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

Frontotemporal dementia (FTD)-causing mutations in the CHMP2B gene lead to the generation of mutant C-terminally truncated CHMP2B. We report that transgenic mice expressing endogenous levels of mutant CHMP2B developed late-onset brain volume loss associated with frank neuronal loss and FTD-like chan...

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Xehetasun bibliografikoak
Argitaratua izan da:Hum Mol Genet
Egile Nagusiak: Clayton, Emma L., Mancuso, Renzo, Nielsen, Troels Tolstrup, Mizielinska, Sarah, Holmes, Holly, Powell, Nicholas, Norona, Frances, Larsen, Jytte Overgaard, Milioto, Carmelo, Wilson, Katherine M., Lythgoe, Mark F., Ourselin, Sebastian, Nielsen, Jörgen E., Johannsen, Peter, Holm, Ida, Collinge, John, Oliver, Peter L., Gomez-Nicola, Diego, Isaacs, Adrian M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2017
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409096/
https://ncbi.nlm.nih.gov/pubmed/28093491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx003
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