Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse

INTRODUCTION: T cell and NK cell cytotoxicity can be mediated via the perforin/granzyme system and Fas Ligand (FasL, CD178). FasL is synthesized as a type II transmembrane protein that binds its cognate receptor Fas (CD95). Membrane‐bound FasL is expressed on the plasma membrane of activated lymphoc...

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Bibliografski detalji
Izdano u:Immun Inflamm Dis
Glavni autori: Lee, Jeansun, Dieckmann, Nele M.G., Edgar, James R., Griffiths, Gillian M., Siegel, Richard M.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946154/
https://ncbi.nlm.nih.gov/pubmed/29642281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iid3.219
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