Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

Cytotoxic T lymphocytes (CTLs) use polarized secretion to rapidly destroy virally infected and tumor cells. To understand the temporal relationships between key events leading to secretion, we used high-resolution 4D imaging. CTLs approached targets with actin-rich projections at the leading edge, c...

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Udgivet i:Immunity
Main Authors: Ritter, Alex T., Asano, Yukako, Stinchcombe, Jane C., Dieckmann, N.M.G., Chen, Bi-Chang, Gawden-Bone, C., van Engelenburg, Schuyler, Legant, Wesley, Gao, Liang, Davidson, Michael W., Betzig, Eric, Lippincott-Schwartz, Jennifer, Griffiths, Gillian M.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448150/
https://ncbi.nlm.nih.gov/pubmed/25992860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.04.013
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