Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes

CD8(+) cytotoxic T lymphocytes (CTLs) eliminate virally infected cells through directed secretion of specialized lytic granules. Because a single CTL can kill multiple targets, degranulation must be tightly regulated. However, how CTLs regulate the termination of granule secretion remains unclear. P...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Ritter, Alex T., Kapnick, Senta M., Murugesan, Sricharan, Schwartzberg, Pamela L., Griffiths, Gillian M., Lippincott-Schwartz, Jennifer
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559056/
https://ncbi.nlm.nih.gov/pubmed/28716933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710751114
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