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PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes

How cytotoxic T lymphocytes (CTLs) sense T cell receptor (TCR) signaling in order to specialize an area of plasma membrane for granule secretion is not understood. Here, we demonstrate that immune synapse formation led to rapid localized changes in the phosphoinositide composition of the plasma memb...

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Bibliografski detalji
Izdano u:Immunity
Glavni autori: Gawden-Bone, Christian M., Frazer, Gordon L., Richard, Arianne C., Ma, Claire Y., Strege, Katharina, Griffiths, Gillian M.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162341/
https://ncbi.nlm.nih.gov/pubmed/30217409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.08.017
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