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PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes

How cytotoxic T lymphocytes (CTLs) sense T cell receptor (TCR) signaling in order to specialize an area of plasma membrane for granule secretion is not understood. Here, we demonstrate that immune synapse formation led to rapid localized changes in the phosphoinositide composition of the plasma memb...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Gawden-Bone, Christian M., Frazer, Gordon L., Richard, Arianne C., Ma, Claire Y., Strege, Katharina, Griffiths, Gillian M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162341/
https://ncbi.nlm.nih.gov/pubmed/30217409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.08.017
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