Key roles of EMT for adaptive resistance to MEK inhibitor in KRAS mutant lung cancer

door Kitai, Hidenori, Ebi, Hiromichi
Gepubliceerd in Small GTPases (2016)

Precision Oncology and the Universal Health Coverage System in Japan

door Ebi, Hiromichi, Bando, Hideaki
Gepubliceerd in JCO Precis Oncol (2019)

Respecting your elders: osimertinib demonstrates preferential activity in elderly patients with T790M positive non-small cell lung cancers

door Ebi, Hiromichi, Boikos, Sosipatros, Faber, Anthony C.
Gepubliceerd in J Thorac Dis (2019)

Not just gRASping at flaws: Finding vulnerabilities to develop novel therapies for treating KRAS mutant cancers

door Ebi, Hiromichi, Faber, Anthony C, Engelman, Jeffrey A, Yano, Seiji
Gepubliceerd in Cancer Sci (2014)

Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells

door Tanimoto, Azusa, Yamada, Tadaaki, Nanjo, Shigeki, Takeuchi, Shinji, Ebi, Hiromichi, Kita, Kenji, Matsumoto, Kunio, Yano, Seiji
Gepubliceerd in 2014

Pulmonary carcinosarcoma showing an obvious response to pazopanib: a case report

door Tanimoto, Azusa, Takeuchi, Shinji, Kotani, Hiroshi, Yamashita, Kaname, Yamada, Tadaaki, Ohtsubo, Koushiro, Ebi, Hiromichi, Ikeda, Hiroko, Yano, Seiji
Gepubliceerd in BMC Pulm Med (2018)

Japanese Society of Medical Oncology Clinical Guidelines: RAS (KRAS/NRAS) mutation testing in colorectal cancer patients11

door Taniguchi, Hiroya, Yamazaki, Kentaro, Yoshino, Takayuki, Muro, Kei, Yatabe, Yasushi, Watanabe, Toshiaki, Ebi, Hiromichi, Ochiai, Atsushi, Baba, Eishi, Tsuchihara, Katsuya
Gepubliceerd in Cancer Sci (2015)

High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells

door Nanjo, Shigeki, Ebi, Hiromichi, Arai, Sachiko, Takeuchi, Shinji, Yamada, Tadaaki, Mochizuki, Satsuki, Okada, Yasunori, Nakada, Mitsutoshi, Murakami, Takashi, Yano, Seiji
Gepubliceerd in Oncotarget (2015)

Japanese Society of Medical Oncology Clinical Guidelines: Molecular Testing for Colorectal Cancer Treatment, 4th edition

door Ebi, Hiromichi, Bando, Hideaki, Taniguchi, Hiroya, Sunakawa, Yu, Okugawa, Yoshinaga, Hatanaka, Yutaka, Hosoda, Waki, Kumamoto, Kensuke, Nakatani, Kaname, Yamazaki, Kentaro
Gepubliceerd in Cancer Sci (2020)

Epithelial-to-mesenchymal transition defines feedback activation of receptor tyrosine kinase signaling induced by MEK inhibition in KRAS mutant lung cancer

door Kitai, Hidenori, Ebi, Hiromichi, Tomida, Shuta, Floros, Konstantinos V., Kotani, Hiroshi, Adachi, Yuta, Oizumi, Satoshi, Nishimura, Masaharu, Faber, Anthony C., Yano, Seiji
Gepubliceerd in Cancer Discov (2016)

Japanese Society of Medical Oncology Clinical Guidelines: Molecular Testing for Colorectal Cancer Treatment, Third Edition

door Yamazaki, Kentaro, Taniguchi, Hiroya, Yoshino, Takayuki, Akagi, Kiwamu, Ishida, Hideyuki, Ebi, Hiromichi, Nakatani, Kaname, Muro, Kei, Yatabe, Yasushi, Yamaguchi, Kensei, Tsuchihara, Katsuya
Gepubliceerd in Cancer Sci (2018)

Ability of the Met Kinase Inhibitor Crizotinib and New Generation EGFR Inhibitors to Overcome Resistance to EGFR Inhibitors

door Nanjo, Shigeki, Yamada, Tadaaki, Nishihara, Hiroshi, Takeuchi, Shinji, Sano, Takako, Nakagawa, Takayuki, Ishikawa, Daisuke, Zhao, Lu, Ebi, Hiromichi, Yasumoto, Kazuo, Matsumoto, Kunio, Yano, Seiji
Gepubliceerd in 2013

Recurrence of renal cell carcinoma diagnosed using contralateral adrenal biopsy with endoscopic ultrasound-guided fine-needle aspiration

door TANIMOTO, AZUSA, TAKEUCHI, SHINJI, YAEGASHI, HIROSHI, KOTANI, HIROSHI, KITAI, HIDENORI, NANJO, SHIGEKI, EBI, HIROMICHI, YAMASHITA, KANAME, MOURI, HISATSUGU, OHTSUBO, KOUSHIRO, IKEDA, HIROKO, YANO, SEIJI
Gepubliceerd in Mol Clin Oncol (2016)

Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK

door Katayama, Ryohei, Khan, Tahsin M., Benes, Cyril, Lifshits, Eugene, Ebi, Hiromichi, Rivera, Victor M., Shakespeare, William C., Iafrate, A. John, Engelman, Jeffrey A., Shaw, Alice T.
Gepubliceerd in 2011

Triple Inhibition of EGFR, Met, and VEGF Suppresses Regrowth of HGF-Triggered, Erlotinib-Resistant Lung Cancer Harboring an EGFR Mutation

door Nakade, Junya, Takeuchi, Shinji, Nakagawa, Takayuki, Ishikawa, Daisuke, Sano, Takako, Nanjo, Shigeki, Yamada, Tadaaki, Ebi, Hiromichi, Zhao, Lu, Yasumoto, Kazuo, Matsumoto, Kunio, Yonekura, Kazuhiko, Yano, Seiji
Gepubliceerd in 2014

Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers co-driven by mutant EGFR containing T790M and MET

door Xu, Lu, Kikuchi, Eiki, Xu, Chunxiao, Ebi, Hiromichi, Ercan, Dalia, Cheng, Katherine A., Padera, Robert, Engelman, Jeffrey A., Jänne, Pasi A., Shapiro, Geoffrey I., Shimamura, Takeshi, Wong, Kwok-Kin
Gepubliceerd in 2012

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1

door Ebi, Hiromichi, Costa, Carlotta, Faber, Anthony C., Nishtala, Madhuri, Kotani, Hiroshi, Juric, Dejan, Della Pelle, Patricia, Song, Youngchul, Yano, Seiji, Mino-Kenudson, Mari, Benes, Cyril H., Engelman, Jeffrey A.
Gepubliceerd in 2013

mTOR Inhibitors Control the Growth of EGFR Mutant Lung Cancer Even after Acquiring Resistance by HGF

door Ishikawa, Daisuke, Takeuchi, Shinji, Nakagawa, Takayuki, Sano, Takako, Nakade, Junya, Nanjo, Shigeki, Yamada, Tadaaki, Ebi, Hiromichi, Zhao, Lu, Yasumoto, Kazuo, Nakamura, Takahiro, Matsumoto, Kunio, Kagamu, Hiroshi, Yoshizawa, Hirohisa, Yano, Seiji
Gepubliceerd in 2013

Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

door Ebi, Hiromichi, Corcoran, Ryan B., Singh, Anurag, Chen, Zhao, Song, Youngchul, Lifshits, Eugene, Ryan, David P., Meyerhardt, Jeffrey A., Benes, Cyril, Settleman, Jeffrey, Wong, Kwok-Kin, Cantley, Lewis C., Engelman, Jeffrey A.
Gepubliceerd in 2011

Measurement of PIP(3) Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer

door Costa, Carlotta, Ebi, Hiromichi, Martini, Miriam, Beausoleil, Sean A., Faber, Anthony C., Jakubik, Charles T., Huang, Alan, Wang, Youzhen, Nishtala, Madhuri, Hall, Ben, Rikova, Klarisa, Zhao, Jean, Hirsch, Emilio, Benes, Cyril H., Engelman, Jeffrey A.
Gepubliceerd in Cancer Cell (2014)