High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells

Leptomeningeal carcinomatosis (LMC) remarkably decreases the quality of life of EGFR-mutant lung cancer patients. In contrast to the lesions outside the central nervous system (CNS), molecular mechanisms of EGFR tyrosine kinase inhibitor (TKI) resistance in CNS lesions including LMC are largely unkn...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nanjo, Shigeki, Ebi, Hiromichi, Arai, Sachiko, Takeuchi, Shinji, Yamada, Tadaaki, Mochizuki, Satsuki, Okada, Yasunori, Nakada, Mitsutoshi, Murakami, Takashi, Yano, Seiji
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826174/
https://ncbi.nlm.nih.gov/pubmed/26716903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6758
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