High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells

Leptomeningeal carcinomatosis (LMC) remarkably decreases the quality of life of EGFR-mutant lung cancer patients. In contrast to the lesions outside the central nervous system (CNS), molecular mechanisms of EGFR tyrosine kinase inhibitor (TKI) resistance in CNS lesions including LMC are largely unkn...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Nanjo, Shigeki, Ebi, Hiromichi, Arai, Sachiko, Takeuchi, Shinji, Yamada, Tadaaki, Mochizuki, Satsuki, Okada, Yasunori, Nakada, Mitsutoshi, Murakami, Takashi, Yano, Seiji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2015
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826174/
https://ncbi.nlm.nih.gov/pubmed/26716903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6758
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