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High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells

Leptomeningeal carcinomatosis (LMC) remarkably decreases the quality of life of EGFR-mutant lung cancer patients. In contrast to the lesions outside the central nervous system (CNS), molecular mechanisms of EGFR tyrosine kinase inhibitor (TKI) resistance in CNS lesions including LMC are largely unkn...

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發表在:Oncotarget
Main Authors: Nanjo, Shigeki, Ebi, Hiromichi, Arai, Sachiko, Takeuchi, Shinji, Yamada, Tadaaki, Mochizuki, Satsuki, Okada, Yasunori, Nakada, Mitsutoshi, Murakami, Takashi, Yano, Seiji
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826174/
https://ncbi.nlm.nih.gov/pubmed/26716903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6758
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