The Influence of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Naldemedine

door Fukumura, Kazuya, Yamada, Tadaaki, Yokota, Takaaki, Kawasaki, Akira
Gepubliceerd in Clin Pharmacol Drug Dev (2019)

Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy: A Subgroup Analysis of Patien...

door Wild, James, Webster, Lynn, Yamada, Tadaaki, Hale, Martin
Gepubliceerd in Drugs Aging (2020)

Ligand‐triggered resistance to molecular targeted drugs in lung cancer: Roles of hepatocyte growth factor and epidermal growth factor receptor ligands

door Yano, Seiji, Takeuchi, Shinji, Nakagawa, Takayuki, Yamada, Tadaaki
Gepubliceerd in Cancer Sci (2012)

A Phase 2b, Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with C...

door Webster, Lynn R, Yamada, Tadaaki, Arjona Ferreira, Juan Camilo
Gepubliceerd in Pain Med (2017)

Onset of action of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: results from 2 randomized, placebo-controlled, phase 3 trial...

door Wild, James, Yamada, Tadaaki, Arjona Ferreira, Juan Camilo, Hale, Martin
Gepubliceerd in Pain (2019)

A Renal Impairment Subgroup Analysis of the Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving O...

door Webster, Lynn R, Hale, Martin E, Yamada, Tadaaki, Wild, James E
Gepubliceerd in J Pain Res (2020)

Effective combined therapy with ramucirumab for advanced pulmonary pleomorphic carcinoma

door Nishioka, Naoya, Kaneko, Yoshiko, Yamada, Tadaaki, Okura, Naoko, Hirai, Soichi, Takayama, Koichi
Gepubliceerd in Respirol Case Rep (2018)

Advanced G‐CSF‐producing non‐small cell lung cancer‐not otherwise specified, with favourable response to pembrolizumab monotherapy

door Matsui, Yohei, Yamada, Tadaaki, Masuzawa, Naoko, Hamada, Shinshichi, Takayama, Koichi, Hiranuma, Osamu
Gepubliceerd in Respirol Case Rep (2020)

Treatment rationale and design of the RAMNITA study: A phase II study of the efficacy of docetaxel + ramucirumab for non–small cell lung cancer with brain metastasis

door Tanimura, Keiko, Uchino, Junji, Tamiya, Nobuyo, Kaneko, Yoshiko, Yamada, Tadaaki, Yoshimura, Kenichi, Takayama, Koichi
Gepubliceerd in Medicine (Baltimore) (2018)

Tumor Neovascularization and Developments in Therapeutics

door Katayama, Yuki, Uchino, Junji, Chihara, Yusuke, Tamiya, Nobuyo, Kaneko, Yoshiko, Yamada, Tadaaki, Takayama, Koichi
Gepubliceerd in Cancers (Basel) (2019)

The role of the gut microbiome on the efficacy of immune checkpoint inhibitors in Japanese responder patients with advanced non-small cell lung cancer

door Katayama, Yuki, Yamada, Tadaaki, Shimamoto, Takayuki, Iwasaku, Masahiro, Kaneko, Yoshiko, Uchino, Junji, Takayama, Koichi
Gepubliceerd in Transl Lung Cancer Res (2019)

Rationale and design of a phase II trial of osimertinib as first-line treatment for elderly patients with epidermal growth factor receptor mutation-positive advanced non-small cell...

door Chihara, Yusuke, Yamada, Tadaaki, Uchino, Junji, Tamiya, Nobuyo, Kaneko, Yoshiko, Kishimoto, Junji, Takayama, Koichi
Gepubliceerd in Transl Lung Cancer Res (2019)

Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells

door Tanimoto, Azusa, Yamada, Tadaaki, Nanjo, Shigeki, Takeuchi, Shinji, Ebi, Hiromichi, Kita, Kenji, Matsumoto, Kunio, Yano, Seiji
Gepubliceerd in 2014

Treatment rationale and design of the SPIRAL study: A phase II trial of osimertinib in elderly epidermal growth factor receptor T790M-positive nonsmall-cell lung cancer patients wh...

door Uchino, Junji, Nakao, Akira, Tamiya, Nobuyo, Kaneko, Yoshiko, Yamada, Tadaaki, Yoshimura, Kenichi, Fujita, Masaki, Takayama, Koichi
Gepubliceerd in Medicine (Baltimore) (2018)

Safety and Usefulness of Cryobiopsy and Stamp Cytology for the Diagnosis of Peripheral Pulmonary Lesions

door Imabayashi, Tatsuya, Uchino, Junji, Yoshimura, Akihiro, Chihara, Yusuke, Tamiya, Nobuyo, Kaneko, Yoshiko, Yamada, Tadaaki, Takayama, Koichi
Gepubliceerd in Cancers (Basel) (2019)

A transcriptional signature identifies LKB1 functional status as a novel determinant of MEK sensitivity in lung adenocarcinoma

door Kaufman, Jacob M., Yamada, Tadaaki, Park, Kyungho, Timmers, Cynthia D., Amann, Joseph M., Carbone, David P.
Gepubliceerd in Cancer Res (2016)

Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: a randomized, double-blind, placebo-controlled phase 3 study

door Webster, Lynn R., Nalamachu, Srinivas, Morlion, Bart, Reddy, Jyotsna, Baba, Yuko, Yamada, Tadaaki, Arjona Ferreira, Juan C.
Gepubliceerd in Pain (2018)

Naldemedine is effective in the treatment of opioid-induced constipation in patients with chronic non-cancer pain who had a poor response to laxatives

door Hale, Martin E., Wild, James E., Yamada, Tadaaki, Yokota, Takaaki, Tack, Jan, Andresen, Viola, Drewes, Asbjørn Mohr
Gepubliceerd in Therap Adv Gastroenterol (2021)

Efficacy and safety of 40 mg or 60 mg duloxetine in Japanese adults with diabetic neuropathic pain: Results from a randomized, 52‐week, open‐label study

door Yasuda, Hitoshi, Hotta, Nigishi, Kasuga, Masato, Kashiwagi, Atsunori, Kawamori, Ryuzo, Yamada, Tadaaki, Baba, Yuko, Alev, Levent, Nakajo, Ko
Gepubliceerd in J Diabetes Investig (2015)

Pulmonary carcinosarcoma showing an obvious response to pazopanib: a case report

door Tanimoto, Azusa, Takeuchi, Shinji, Kotani, Hiroshi, Yamashita, Kaname, Yamada, Tadaaki, Ohtsubo, Koushiro, Ebi, Hiromichi, Ikeda, Hiroko, Yano, Seiji
Gepubliceerd in BMC Pulm Med (2018)