Triple Inhibition of EGFR, Met, and VEGF Suppresses Regrowth of HGF-Triggered, Erlotinib-Resistant Lung Cancer Harboring an EGFR Mutation

INTRODUCTION: Met activation by gene amplification and its ligand, hepatocyte growth factor (HGF), imparts resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant lung cancer. We recently reported that Met activation by HGF stimulates the production of...

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Detalhes bibliográficos
Main Authors: Nakade, Junya, Takeuchi, Shinji, Nakagawa, Takayuki, Ishikawa, Daisuke, Sano, Takako, Nanjo, Shigeki, Yamada, Tadaaki, Ebi, Hiromichi, Zhao, Lu, Yasumoto, Kazuo, Matsumoto, Kunio, Yonekura, Kazuhiko, Yano, Seiji
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132034/
https://ncbi.nlm.nih.gov/pubmed/24828661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000170
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