Telomerase-Independent Paths to Immortality in Predictable Cancer Subtypes

Por Durant, Stephen T
Publicado em 2012

Vanillins—a novel family of DNA-PK inhibitors

Por Durant, Stephen, Karran, Peter
Publicado em 2003

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes

Por Ward, Thomas A., McHugh, Peter J., Durant, Stephen T.
Publicado no PLoS One (2017)

UV Radiation Induces Delayed Hyperrecombination Associated with Hypermutation in Human Cells

Por Durant, Stephen T., Paffett, Kimberly S., Shrivastav, Meena, Timmins, Graham S., Morgan, William F., Nickoloff, Jac A.
Publicado em 2006

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Por Tebay, Lauren E., Robertson, Holly, Durant, Stephen T., Vitale, Steven R., Penning, Trevor M., Dinkova-Kostova, Albena T., Hayes, John D.
Publicado no Free Radic Biol Med (2015)

DNA-PKcs and ATM Co-Regulate DNA Double-Strand Break Repair

Por Shrivastav, Meena, Miller, Cheryl A., De Haro, Leyma P., Durant, Stephen T., Chen, Benjamin P.C., Chen, David J., Nickoloff, Jac A.
Publicado em 2009

The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair

Por Lee, Suk-Hee, Oshige, Masahiko, Durant, Stephen T., Rasila, Kanwaldeep Kaur, Williamson, Elizabeth A., Ramsey, Heather, Kwan, Lori, Nickoloff, Jac A., Hromas, Robert
Publicado em 2005

Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives

Por Tucker, Julie A., Bennett, Neil, Brassington, Claire, Durant, Stephen T., Hassall, Giles, Holdgate, Geoff, McAlister, Mark, Nissink, J. Willem M., Truman, Caroline, Watson, Martin
Publicado em 2012

Metnase promotes restart and repair of stalled and collapsed replication forks

Por De Haro, Leyma P., Wray, Justin, Williamson, Elizabeth A., Durant, Stephen T., Corwin, Lori, Gentry, Amanda C., Osheroff, Neil, Lee, Suk-Hee, Hromas, Robert, Nickoloff, Jac A.
Publicado em 2010

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells

Por James, Dominic I., Durant, Stephen, Eckersley, Kay, Fairweather, Emma, Griffiths, Louise A., Hamilton, Nicola, Kelly, Paul, O'Connor, Mark, Shea, Kerry, Waddell, Ian D., Ogilvie, Donald J.
Publicado no F1000Res (2016)

Cellular Active N-Hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site

Por Exell, Jack C., Thompson, Mark J., Finger, L. David, Shaw, Steven J., Debreczeni, Judit, Ward, Thomas A., McWhirter, Claire, Siöberg, Catrine L. B., Martinez Molina, Daniel, Mark Abbott, W., Jones, Clifford D., Nissink, J. Willem M., Durant, Stephen T., Grasby, Jane A.
Publicado no Nat Chem Biol (2016)

Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors

Por Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Colclough, Nicola, Dishington, Allan, Durant, Stephen, Goldberg, Kristin, Hassall, Lorraine A., Hughes, Gareth D., MacFaul, Philip A., McGuire, Thomas M., Pass, Martin, Patel, Anil, Pearson, Stuart, Petersen, Jens, Pike, Kurt G., Robb, Graeme, Stratton, Natalie, Xin, Guohong, Zhai, Baochang
Publicado no ACS Med Chem Lett (2018)

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Por Balmus, Gabriel, Pilger, Domenic, Coates, Julia, Demir, Mukerrem, Sczaniecka-Clift, Matylda, Barros, Ana C., Woods, Michael, Fu, Beiyuan, Yang, Fengtang, Chen, Elisabeth, Ostermaier, Matthias, Stankovic, Tatjana, Ponstingl, Hannes, Herzog, Mareike, Yusa, Kosuke, Martinez, Francisco Munoz, Durant, Stephen T., Galanty, Yaron, Beli, Petra, Adams, David J., Bradley, Allan, Metzakopian, Emmanouil, Forment, Josep V., Jackson, Stephen P.
Publicado no Nat Commun (2019)

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

Por Durant, Stephen T., Zheng, Li, Wang, Yingchun, Chen, Kan, Zhang, Lingli, Zhang, Tianwei, Yang, Zhenfan, Riches, Lucy, Trinidad, Antonio G., Fok, Jacqueline H. L., Hunt, Tom, Pike, Kurt G., Wilson, Joanne, Smith, Aaron, Colclough, Nicola, Reddy, Venkatesh Pilla, Sykes, Andrew, Janefeldt, Annika, Johnström, Peter, Varnäs, Katarina, Takano, Akihiro, Ling, Stephanie, Orme, Jonathan, Stott, Jonathan, Roberts, Caroline, Barrett, Ian, Jones, Gemma, Roudier, Martine, Pierce, Andrew, Allen, Jasmine, Kahn, Jenna, Sule, Amrita, Karlin, Jeremy, Cronin, Anna, Chapman, Melissa, Valerie, Kristoffer, Illingworth, Ruth, Pass, Martin
Publicado no Sci Adv (2018)

Orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice

Por Karlin, Jeremy, Allen, Jasmine, Ahmad, Syed F., Hughes, Gareth, Sheridan, Victoria, Odedra, Rajesh, Farrington, Paul, Cadogan, Elaine B., Riches, Lucy C., Garcia-Trinidad, Antonio, Thomason, Andrew G., Patel, Bhavika, Vincent, Jennifer, Lau, Alan, Pike, Kurt G., Hunt, Thomas A., Sule, Amrita, Valerie, Nicholas C.K., Biddlestone-Thorpe, Laura, Kahn, Jenna, Beckta, Jason M., Mukhopadhyay, Nitai, Barlaam, Bernard, Degorce, Sebastien L., Kettle, Jason, Colclough, Nicola, Wilson, Joanne, Smith, Aaron, Barrett, Ian P., Zheng, Li, Zhang, Tianwei, Wang, Yingchun, Chen, Kan, Pass, Martin, Durant, Stephen T., Valerie, Kristoffer
Publicado no Mol Cancer Ther (2018)