A recessive cellular mutation in v-fes-transformed mink cells restores contact inhibition and anchorage-dependent growth.

Por Haynes, J R, Downing, J R
Publicado em 1988

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein...

Por Meyers, S, Downing, J R, Hiebert, S W
Publicado em 1993

Induction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetate.

Por Luo, T, Downing, J R, Garcia, J V
Publicado em 1997

Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for phosphatidylinositol 3-kinase.

Por Downing, J R, Shurtleff, S A, Sherr, C J
Publicado em 1991

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

Por Downing, J R, Roussel, M F, Sherr, C J
Publicado em 1989

Ligand-induced tyrosine kinase activity of the colony-stimulating factor 1 receptor in a murine macrophage cell line.

Por Downing, J R, Rettenmier, C W, Sherr, C J
Publicado em 1988

A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylino...

Por Roussel, M F, Shurtleff, S A, Downing, J R, Sherr, C J
Publicado em 1990

Ligand-induced phosphorylation of the colony-stimulating factor 1 receptor can occur through an intermolecular reaction that triggers receptor down modulation.

Por Ohtsuka, M, Roussel, M F, Sherr, C J, Downing, J R
Publicado em 1990

Phenylindanedione: An Anticoagulant

Por Townsend, S. R., Fay, K. J., Downing, J. R., Laing, R., Cameron, Douglas G.
Publicado em 1953

Colony-stimulating factor 1-mediated regulation of a chimeric c-fms/v-fms receptor containing the v-fms-encoded tyrosine kinase domain.

Por Roussel, M F, Downing, J R, Ashmun, R A, Rettenmier, C W, Sherr, C J
Publicado em 1988

Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase.

Por Shurtleff, S A, Downing, J R, Rock, C O, Hawkins, S A, Roussel, M F, Sherr, C J
Publicado em 1990

Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.

Por Downing, J R, Margolis, B L, Zilberstein, A, Ashmun, R A, Ullrich, A, Sherr, C J, Schlessinger, J
Publicado em 1989

The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.

Por Hiebert, S W, Sun, W, Davis, J N, Golub, T, Shurtleff, S, Buijs, A, Downing, J R, Grosveld, G, Roussell, M F, Gilliland, D G, Lenny, N, Meyers, S
Publicado em 1996

Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma.

Por Downing, J. R., Khandekar, A., Shurtleff, S. A., Head, D. R., Parham, D. M., Webber, B. L., Pappo, A. S., Hulshof, M. G., Conn, W. P., Shapiro, D. N.
Publicado em 1995

Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction.

Por Downing, J. R., Head, D. R., Parham, D. M., Douglass, E. C., Hulshof, M. G., Link, M. P., Motroni, T. A., Grier, H. E., Curcio-Brint, A. M., Shapiro, D. N.
Publicado em 1993

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

Por Pomeroy, E J, Lee, L A, Lee, R D W, Schirm, D K, Temiz, N A, Ma, J, Gruber, T A, Diaz-Flores, E, Moriarity, B S, Downing, J R, Shannon, K M, Largaespada, D A, Eckfeldt, C E
Publicado no Oncogene (2017)

Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

Por Roberts, K.G., Li, Y., Payne-Turner, D., Harvey, R.C., Yang, Y.-L., Pei, D., McCastlain, K., Ding, L., Lu, C., Song, G., Ma, J., Becksfort, J., Rusch, M., Chen, S.-C., Easton, J., Cheng, J., Boggs, K., Santiago-Morales, N., Iacobucci, I., Fulton, R.S., Wen, J., Valentine, M., Cheng, C., Paugh, S.W., Devidas, M., Chen, I-M., Reshmi, S., Smith, A., Hedlund, E., Gupta, P., Nagahawatte, P., Wu, G., Chen, X., Yergeau, D., Vadodaria, B., Mulder, H., Winick, N.J., Larsen, E.C., Carroll, W.L., Heerema, N.A., Carroll, A.J., Grayson, G., Tasian, S.K., Moore, A.S., Keller, F., Frei-Jones, M., Whitlock, J.A., Raetz, E.A., White, D.L., Hughes, T.P., Auvil, J.M. Guidry, Smith, M.A., Marcucci, G., Bloomfield, C.D., Mrózek, K., Kohlschmidt, J., Stock, W., Kornblau, S.M., Konopleva, M., Paietta, E., Pui, C.-H., Jeha, S., Relling, M.V., Evans, W.E., Gerhard, D.S., Gastier-Foster, J.M., Mardis, E., Wilson, R.K., Loh, M.L., Downing, J.R., Hunger, S.P., Willman, C.L., Zhang, J., Mullighan, C.G.
Publicado em 2014