The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.

The t(12;21) translocation is present in up to 30% of childhood B-cell acute lymphoblastic and fuses a potential dimerization motif from the ets-related factor TEL to the N terminus of AML1. The t(12;21) translocation encodes a 93-kDa fusion protein that localizes to a high-salt- and detergent-resis...

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Detalhes bibliográficos
Main Authors: Hiebert, S W, Sun, W, Davis, J N, Golub, T, Shurtleff, S, Buijs, A, Downing, J R, Grosveld, G, Roussell, M F, Gilliland, D G, Lenny, N, Meyers, S
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC231119/
https://ncbi.nlm.nih.gov/pubmed/8657108
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