Both TEL and AML-1 Contribute Repression Domains to the t(12;21) Fusion Protein

t(12;21) is the most frequent translocation found in pediatric B-cell acute lymphoblastic leukemias. This translocation fuses a putative repressor domain from the TEL DNA-binding protein to nearly all of the AML-1B transcription factor. Here, we demonstrate that fusion of the TEL pointed domain to t...

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Bibliografiske detaljer
Main Authors: Fenrick, Randy, Amann, Joseph M., Lutterbach, Bart, Wang, Lilin, Westendorf, Jennifer J., Downing, James R., Hiebert, Scott W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC84626/
https://ncbi.nlm.nih.gov/pubmed/10490596
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