Modeling disease in vivo with CRISPR/Cas9

Por Dow, Lukas E.
Publicado no Trends Mol Med (2015)

Life in the Fast Lane: Mammalian Disease Models in the Genomics Era

Por Dow, Lukas E., Lowe, Scott W.
Publicado em 2012

Somatic Genome Editing Goes Viral

Por Zafra, Maria Paz, Dow, Lukas E.
Publicado no Trends Mol Med (2016)

Wnt Signaling and Colorectal Cancer

Por Schatoff, Emma M., Leach, Benjamin I., Dow, Lukas E.
Publicado no Curr Colorectal Cancer Rep (2017)

Immunofluorescent Staining of Mouse Intestinal Stem Cells

Por O’Rourke, Kevin P., Dow, Lukas E, Lowe, Scott W
Publicado no Bio Protoc (2016)

Isolation, Culture, and Maintenance of Mouse Intestinal Stem Cells

Por O’Rourke, Kevin P., Ackerman, Sarah, Dow, Lukas E, Lowe, Scott W
Publicado no Bio Protoc (2016)

Creating Transgenic shRNA Mice by Recombinase-Mediated Cassette Exchange

Por Premsrirut, Prem K., Dow, Lukas E., Park, Youngkyu, Hannon, Gregory J., Lowe, Scott W.
Publicado em 2013

R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

Por Han, Teng, Schatoff, Emma M., Murphy, Charles, Zafra, Maria Paz, Wilkinson, John E., Elemento, Olivier, Dow, Lukas E.
Publicado no Nat Commun (2017)

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi

Por Zuber, Johannes, McJunkin, Katherine, Fellmann, Christof, Dow, Lukas E, Taylor, Meredith J, Hannon, Gregory J, Lowe, Scott W
Publicado em 2010

A modular and flexible ESC-based mouse model of pancreatic cancer

Por Saborowski, Michael, Saborowski, Anna, Morris, John P., Bosbach, Benedikt, Dow, Lukas E., Pelletier, Jerry, Klimstra, David S., Lowe, Scott W.
Publicado em 2014

Reversible suppression of an essential gene in adult mice using transgenic RNA interference

Por McJunkin, Katherine, Mazurek, Anthony, Premsrirut, Prem K., Zuber, Johannes, Dow, Lukas E., Simon, Janelle, Stillman, Bruce, Lowe, Scott W.
Publicado em 2011

Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice

Por Dow, Lukas E., Nasr, Zeina, Saborowski, Michael, Ebbesen, Saya H., Manchado, Eusebio, Tasdemir, Nilgun, Lee, Teresa, Pelletier, Jerry, Lowe, Scott W.
Publicado em 2014

The Polarity Protein Scribble Regulates Myelination and Remyelination in the Central Nervous System

Por Jarjour, Andrew A., Boyd, Amanda, Dow, Lukas E., Holloway, Rebecca K., Goebbels, Sandra, Humbert, Patrick O., Williams, Anna, ffrench-Constant, Charles
Publicado no PLoS Biol (2015)

Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer

Por Dow, Lukas E, O’Rourke, Kevin P, Simon, Janelle, Tschaharganeh, Darjus F, van Es, Johan H, Clevers, Hans, Lowe, Scott W
Publicado no Cell (2015)

Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition

Por Bolden, Jessica E., Tasdemir, Nilgun, Dow, Lukas E., van Es, Johan H., Wilkinson, John E., Zhao, Zhen, Clevers, Hans, Lowe, Scott W.
Publicado no Cell Rep (2014)

Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia

Por Nasr, Zeina, Dow, Lukas E, Paquet, Marilene, Chu, Jennifer, Ravindar, Kontham, Somaiah, Ragam, Deslongchamps, Pierre, Porco Jr, John A, Lowe, Scott W, Pelletier, Jerry
Publicado no BMC Pharmacol Toxicol (2013)

Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas

Por Ebbesen, Saya H., Scaltriti, Maurizio, Bialucha, Carl U., Morse, Natasha, Kastenhuber, Edward R., Wen, Hannah Y., Dow, Lukas E., Baselga, José, Lowe, Scott W.
Publicado no Proc Natl Acad Sci U S A (2016)

Variability of Inducible Expression across the Hematopoietic System of Tetracycline Transactivator Transgenic Mice

Por Takiguchi, Megumi, Dow, Lukas E., Prier, Julia E., Carmichael, Catherine L., Kile, Benjamin T., Turner, Stephen J., Lowe, Scott W., Huang, David C. S., Dickins, Ross A.
Publicado em 2013

Inducible in vivo genome editing with CRISPR/Cas9

Por Dow, Lukas E, Fisher, Jonathan, O'Rourke, Kevin P, Muley, Ashlesha, Kastenhuber, Edward R, Livshits, Geulah, Tschaharganeh, Darjus F, Socci, Nicholas D, Lowe, Scott W
Publicado no Nat Biotechnol (2015)

A pipeline for the generation of shRNA transgenic mice

Por Dow, Lukas E, Premsrirut, Prem K, Zuber, Johannes, Fellmann, Christof, McJunkin, Katherine, Miething, Cornelius, Park, Youngkyu, Dickins, Ross A, Hannon, Gregory J, Lowe, Scott W
Publicado em 2012