Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas

Loss of the tumor suppressor gene PTEN is implicated in breast cancer progression and resistance to targeted therapies, and is thought to promote tumorigenesis by activating PI3K signaling. In a transgenic model of breast cancer, Pten suppression using a tetracycline-regulatable short hairpin (sh)RN...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ebbesen, Saya H., Scaltriti, Maurizio, Bialucha, Carl U., Morse, Natasha, Kastenhuber, Edward R., Wen, Hannah Y., Dow, Lukas E., Baselga, José, Lowe, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801318/
https://ncbi.nlm.nih.gov/pubmed/26929372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523693113
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