The elusive middle domain of Hsp104 and ClpB: location and function

Por DeSantis, Morgan E., Shorter, James
Publicado em 2011

Hsp104 Drives ‘Protein-Only’ Positive Selection of Sup35 Prion Strains Encoding Strong [PSI(+)]

Por DeSantis, Morgan E., Shorter, James
Publicado em 2012

Purification of Hsp104, a Protein Disaggregase

Por Sweeny, Elizabeth A., DeSantis, Morgan E., Shorter, James
Publicado em 2011

Mechanism and Regulation of Cytoplasmic Dynein

Por Cianfrocco, Michael A., DeSantis, Morgan E., Leschziner, Andres E., Reck-Peterson, Samara L.
Publicado no Annu Rev Cell Dev Biol (2015)

Conserved Distal Loop Residues in the Hsp104 and ClpB Middle Domain Contact Nucleotide-binding Domain 2 and Enable Hsp70-dependent Protein Disaggregation

Por DeSantis, Morgan E., Sweeny, Elizabeth A., Snead, David, Leung, Eunice H., Go, Michelle S., Gupta, Kushol, Wendler, Petra, Shorter, James
Publicado em 2014

Lis1 has two opposing modes of regulating cytoplasmic dynein

Por DeSantis, Morgan E., Cianfrocco, Michael A., Htet, Zaw Min, Tran, Phuoc Tien, Reck-Peterson, Samara L., Leschziner, Andres E.
Publicado no Cell (2017)

Light Chain Somatic Mutations Change Thermodynamics of Binding and Water Coordination in the HyHEL-10 Family of Antibodies

Por Acchione, Mauro, Lipschultz, Claudia A., DeSantis, Morgan, Shanmuganathan, Aranganathan, Li, Mi, Wlodawer, Alexander, Tarasov, Sergey, Smith-Gill, Sandra J.
Publicado no Mol Immunol (2009)

The Hsp104 N-Terminal Domain Enables Disaggregase Plasticity and Potentiation

Por Sweeny, Elizabeth A., Jackrel, Meredith E., Go, Michelle S., Sochor, Matthew A., Razzo, Beatrice M., DeSantis, Morgan E., Gupta, Kushol, Shorter, James
Publicado no Mol Cell (2015)

Association Energetics of Cross-reactive and Specific Antibodies

Por Mohan, S., Kourentzi, Katerina, Schick, Kari A., Uehara, Christian, Lipschultz, Claudia A., Acchione, Mauro, DeSantis, Morgan E., Smith-Gill, Sandra J., Willson, Richard C.
Publicado em 2009

Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

Por Jackrel, Meredith E., DeSantis, Morgan E., Martinez, Bryan A., Castellano, Laura M., Stewart, Rachel M., Caldwell, Kim A., Caldwell, Guy A., Shorter, James
Publicado em 2014

Fission Yeast Does Not Age under Favorable Conditions, but Does So after Stress

Por Coelho, Miguel, Dereli, Aygül, Haese, Anett, Kühn, Sebastian, Malinovska, Liliana, DeSantis, Morgan E., Shorter, James, Alberti, Simon, Gross, Thilo, Tolić-Nørrelykke, Iva M.
Publicado no Curr Biol (2013)

Specific Fluorine Labeling of the HyHEL10 Antibody Affects Antigen Binding and Dynamics

Por Acchione, Mauro, Lee, Yi-Chien, DeSantis, Morgan E., Lipschultz, Claudia A., Wlodawer, Alexander, Li, Mi, Shanmuganathan, Aranganathan, Walter, Richard L., Smith-Gill, Sandra, Barchi, Joseph J.
Publicado em 2012

The human cytoplasmic dynein interactome reveals novel activators of motility

Por Redwine, William B, DeSantis, Morgan E, Hollyer, Ian, Htet, Zaw Min, Tran, Phuoc Tien, Swanson, Selene K, Florens, Laurence, Washburn, Michael P, Reck-Peterson, Samara L
Publicado no eLife (2017)

Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Non-Amyloid Clients

Por DeSantis, Morgan E., Leung, Eunice H., Sweeny, Elizabeth A., Jackrel, Meredith E., Cushman-Nick, Mimi, Neuhaus-Follini, Alexandra, Vashist, Shilpa, Sochor, Matthew A., Knight, M. Noelle, Shorter, James
Publicado em 2012

Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains

Por Guo, Lin, Kim, Hong Joo, Wang, Hejia, Monaghan, John, Freyermuth, Fernande, Sung, Julie C., O’Donovan, Kevin, Fare, Charlotte M., Diaz, Zamia, Singh, Nikita, Zhang, Zi Chao, Coughlin, Maura, Sweeny, Elizabeth A., DeSantis, Morgan E., Jackrel, Meredith E., Rodell, Christopher B., Burdick, Jason A., King, Oliver D., Gitler, Aaron D., Lagier-Tourenne, Clotilde, Pandey, Udai Bhan, Chook, Yuh Min, Taylor, J. Paul, Shorter, James
Publicado no Cell (2018)