Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Non-Amyloid Clients

It is not understood how Hsp104, a hexameric AAA+ ATPase from yeast, disaggregates diverse structures including stress-induced aggregates, prions, and α-synuclein conformers connected to Parkinson disease. Here, we establish that Hsp104 hexamers adapt different mechanisms of intersubunit collaborati...

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Autores principales: DeSantis, Morgan E., Leung, Eunice H., Sweeny, Elizabeth A., Jackrel, Meredith E., Cushman-Nick, Mimi, Neuhaus-Follini, Alexandra, Vashist, Shilpa, Sochor, Matthew A., Knight, M. Noelle, Shorter, James
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496281/
https://ncbi.nlm.nih.gov/pubmed/23141537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.09.038
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