Conserved Distal Loop Residues in the Hsp104 and ClpB Middle Domain Contact Nucleotide-binding Domain 2 and Enable Hsp70-dependent Protein Disaggregation

The homologous hexameric AAA(+) proteins, Hsp104 from yeast and ClpB from bacteria, collaborate with Hsp70 to dissolve disordered protein aggregates but employ distinct mechanisms of intersubunit collaboration. How Hsp104 and ClpB coordinate polypeptide handover with Hsp70 is not understood. Here, w...

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Bibliographische Detailangaben
Hauptverfasser: DeSantis, Morgan E., Sweeny, Elizabeth A., Snead, David, Leung, Eunice H., Go, Michelle S., Gupta, Kushol, Wendler, Petra, Shorter, James
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887210/
https://ncbi.nlm.nih.gov/pubmed/24280225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520759
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