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Purification of Hsp104, a Protein Disaggregase
Hsp104 is a hexameric AAA+ protein(1) from yeast, which couples ATP hydrolysis to protein disaggregation(2-10) (Fig. 1). This activity imparts two key selective advantages. First, renaturation of disordered aggregates by Hsp104 empowers yeast survival after various protein-misfolding stresses, inclu...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MyJove Corporation
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3230206/ https://ncbi.nlm.nih.gov/pubmed/21989490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/3190 |
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