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Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase
Hsp104 is a hexameric AAA(+) ATPase and protein disaggregase found in yeast, which couples ATP hydrolysis to the dissolution of diverse polypeptides trapped in toxic preamyloid oligomers, phase-transitioned gels, disordered aggregates, amyloids, and prions. Hsp104 shows plasticity in disaggregating...
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| Publicado en: | Cold Spring Harb Perspect Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6671941/ https://ncbi.nlm.nih.gov/pubmed/30745294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a034033 |
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