Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

Hsp100 polypeptide translocases are conserved AAA+ machines that maintain proteostasis by unfolding aberrant and toxic proteins for refolding or proteolytic degradation. The Hsp104 disaggregase from S. cerevisiae solubilizes stress-induced amorphous aggregates and amyloid. The structural basis for s...

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Publicado en:Science
Autores principales: Gates, Stephanie N., Yokom, Adam L., Lin, JiaBei, Jackrel, Meredith E., Rizo, Alexandrea N., Kendsersky, Nathan M., Buell, Courtney E., Sweeny, Elizabeth A., Mack, Korrie L., Chuang, Edward, Torrente, Mariana P., Su, Min, Shorter, James, Southworth, Daniel R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770238/
https://ncbi.nlm.nih.gov/pubmed/28619716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan1052
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