Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

Hsp100 polypeptide translocases are conserved AAA+ machines that maintain proteostasis by unfolding aberrant and toxic proteins for refolding or proteolytic degradation. The Hsp104 disaggregase from S. cerevisiae solubilizes stress-induced amorphous aggregates and amyloid. The structural basis for s...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Science
मुख्य लेखकों: Gates, Stephanie N., Yokom, Adam L., Lin, JiaBei, Jackrel, Meredith E., Rizo, Alexandrea N., Kendsersky, Nathan M., Buell, Courtney E., Sweeny, Elizabeth A., Mack, Korrie L., Chuang, Edward, Torrente, Mariana P., Su, Min, Shorter, James, Southworth, Daniel R.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2017
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770238/
https://ncbi.nlm.nih.gov/pubmed/28619716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan1052
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