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Mechanistic and structural insights into the prion-disaggregase activity of Hsp104
Hsp104 is a dynamic ring-translocase and hexameric AAA+ protein found in yeast, which couples ATP hydrolysis to disassembly and reactivation of proteins trapped in soluble preamyloid oligomers, disordered protein aggregates, and stable amyloid or prion conformers. Here, we highlight advances in our...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4860052/ https://ncbi.nlm.nih.gov/pubmed/26608812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.11.016 |
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