Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Non-Amyloid Clients

It is not understood how Hsp104, a hexameric AAA+ ATPase from yeast, disaggregates diverse structures including stress-induced aggregates, prions, and α-synuclein conformers connected to Parkinson disease. Here, we establish that Hsp104 hexamers adapt different mechanisms of intersubunit collaborati...

Full description

Saved in:
Bibliographic Details
Main Authors: DeSantis, Morgan E., Leung, Eunice H., Sweeny, Elizabeth A., Jackrel, Meredith E., Cushman-Nick, Mimi, Neuhaus-Follini, Alexandra, Vashist, Shilpa, Sochor, Matthew A., Knight, M. Noelle, Shorter, James
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496281/
https://ncbi.nlm.nih.gov/pubmed/23141537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.09.038
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items