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Applying Hsp104 to protein-misfolding disorders
Hsp104, a hexameric AAA+ ATPase found in yeast, transduces energy from cycles of ATP binding and hydrolysis to resolve disordered protein aggregates and cross-β amyloid conformers. These disaggregation activities are often co-ordinated by the Hsp70 chaperone system and confer considerable selective...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2933416/ https://ncbi.nlm.nih.gov/pubmed/20130674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1139/o09-121 |
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