Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells

由 Trinidad, A G, Whalley, N, Rowlinson, R, Delpuech, O, Dudley, P, Rooney, C, Critchlow, S E
發表在 Oncogene (2017)

PO27 IDH1 MUTATIONS COMPROMISE THE ADAPTIVE RESPONSE TO HYPOXIA

由 Hollinshead, Kate E.R., Ludwig, Christian, Parker, Seth J., Metallo, Christian M., Critchlow, Susan E., Cruickshank, Garth S., Tennant, Daniel A.
發表在 Neuro Oncol (2015)

CD147 subunit of lactate/H(+) symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

由 Le Floch, Renaud, Chiche, Johanna, Marchiq, Ibtissam, Naiken, Tanesha, Ilc, Karine, Murray, Clare M., Critchlow, Susan E., Roux, Danièle, Simon, Marie-Pierre, Pouysségur, Jacques
出版 2011

Inhibition of Monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport

由 Bola, Becky M., Chadwick, Amy L., Michopoulos, Filippos, Blount, Kathryn G., Telfer, Brian A., Williams, Kaye J., Smith, Paul D, Critchlow, Susan E., Stratford, Ian J.
發表在 Mol Cancer Ther (2014)

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

由 Mehibel, Manal, Ortiz-Martinez, Fernando, Voelxen, Nadine, Boyers, Amy, Chadwick, Amy, Telfer, Brian A., Mueller-Klieser, Wolfgang, West, Catharine M., Critchlow, Susan E., Williams, Kaye J., Stratford, Ian J.
發表在 Sci Rep (2018)

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

由 Jones, Dylan T., Valli, Alessandro, Haider, Syed, Zhang, Qifeng, Smethurst, Elizabeth A., Schug, Zachary T., Peck, Barrie, Aboagye, Eric O., Critchlow, Susan E., Schulze, Almut, Gottlieb, Eyal, Wakelam, Michael J.O., Harris, Adrian L.
發表在 Mol Cancer Ther (2018)

Activity of the Monocarboxylate Transporter 1 inhibitor AZD3965 in Small Cell Lung Cancer

由 Polański, Radosław, Hodgkinson, Cassandra L., Fusi, Alberto, Nonaka, Daisuke, Priest, Lynsey, Kelly, Paul, Trapani, Francesca, Bishop, Paul W., White, Anne, Critchlow, Susan E., Smith, Paul D., Blackhall, Fiona, Dive, Caroline, Morrow, Christopher J.
出版 2013

Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity

由 Curtis, Nicola J., Mooney, Lorraine, Hopcroft, Lorna, Michopoulos, Filippos, Whalley, Nichola, Zhong, Haihong, Murray, Clare, Logie, Armelle, Revill, Mitchell, Byth, Kate F., Benjamin, Amanda D., Firth, Mike A., Green, Stephen, Smith, Paul D., Critchlow, Susan E.
發表在 Oncotarget (2017)

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

由 Noble, Richard A., Bell, Natalie, Blair, Helen, Sikka, Arti, Thomas, Huw, Phillips, Nicole, Nakjang, Sirintra, Miwa, Satomi, Crossland, Rachel, Rand, Vikki, Televantou, Despina, Long, Anna, Keun, Hector C., Bacon, Chris M., Bomken, Simon, Critchlow, Susan E., Wedge, Stephen R.
發表在 Haematologica (2017)

MCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4

由 Hong, Candice Sun, Graham, Nicholas A., Gu, Wen, Camacho, Carolina Espindola, Mah, Vei, Maresh, Erin L., Alavi, Mohammed, Bagryanova, Lora, Krotee, Pascal A. L., Gardner, Brian K., Behbahan, Iman Saramipoor, Horvath, Steve, Chia, David, Mellinghoff, Ingo K., Hurvitz, Sara A., Dubinett, Steven M., Critchlow, Susan E., Kurdistani, Siavash K., Goodglick, Lee, Braas, Daniel, Graeber, Thomas G., Christofk, Heather R.
發表在 Cell Rep (2016)

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

由 Peck, Barrie, Schug, Zachary T., Zhang, Qifeng, Dankworth, Beatrice, Jones, Dylan T., Smethurst, Elizabeth, Patel, Rachana, Mason, Susan, Jiang, Ming, Saunders, Rebecca, Howell, Michael, Mitter, Richard, Spencer-Dene, Bradley, Stamp, Gordon, McGarry, Lynn, James, Daniel, Shanks, Emma, Aboagye, Eric O., Critchlow, Susan E., Leung, Hing Y., Harris, Adrian L., Wakelam, Michael J. O., Gottlieb, Eyal, Schulze, Almut
發表在 Cancer Metab (2016)

AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo

由 Loddick, Sarah A, Ross, Sarah J, Thomason, Andrew G, Robinson, David M, Walker, Graeme E, Dunkley, Tom PJ, Brave, Sandra R, Broadbent, Nicola, Stratton, Natalie C, Trueman, Dawn, Mouchet, Elizabeth, Shaheen, Fadhel S, Jacobs, Vivien N, Cumberbatch, Marie, Wilson, Joanne, Jones, Rhys D O, Bradbury, Robert H, Rabow, Alfred, Gaughan, Luke, Womack, Chris, Barry, Simon T, Robson, Craig N, Critchlow, Susan E, Wedge, Stephen R, Brooks, Nigel A
出版 2013

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

由 Schug, Zachary T., Peck, Barrie, Jones, Dylan T., Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S., Goodwin, Louise M., Smethurst, Elizabeth, Mason, Susan, Blyth, Karen, McGarry, Lynn, James, Daniel, Shanks, Emma, Kalna, Gabriela, Saunders, Rebecca E., Jiang, Ming, Howell, Michael, Lassailly, Francois, Thin, May Zaw, Spencer-Dene, Bradley, Stamp, Gordon, van den Broek, Niels J.F., Mackay, Gillian, Bulusu, Vinay, Kamphorst, Jurre J., Tardito, Saverio, Strachan, David, Harris, Adrian L., Aboagye, Eric O., Critchlow, Susan E., Wakelam, Michael J.O., Schulze, Almut, Gottlieb, Eyal
發表在 Cancer Cell (2015)