Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells

od Trinidad, A G, Whalley, N, Rowlinson, R, Delpuech, O, Dudley, P, Rooney, C, Critchlow, S E
Wydane w Oncogene (2017)

PO27 IDH1 MUTATIONS COMPROMISE THE ADAPTIVE RESPONSE TO HYPOXIA

od Hollinshead, Kate E.R., Ludwig, Christian, Parker, Seth J., Metallo, Christian M., Critchlow, Susan E., Cruickshank, Garth S., Tennant, Daniel A.
Wydane w Neuro Oncol (2015)

CD147 subunit of lactate/H(+) symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

od Le Floch, Renaud, Chiche, Johanna, Marchiq, Ibtissam, Naiken, Tanesha, Ilc, Karine, Murray, Clare M., Critchlow, Susan E., Roux, Danièle, Simon, Marie-Pierre, Pouysségur, Jacques
Wydane 2011

Inhibition of Monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport

od Bola, Becky M., Chadwick, Amy L., Michopoulos, Filippos, Blount, Kathryn G., Telfer, Brian A., Williams, Kaye J., Smith, Paul D, Critchlow, Susan E., Stratford, Ian J.
Wydane w Mol Cancer Ther (2014)

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

od Mehibel, Manal, Ortiz-Martinez, Fernando, Voelxen, Nadine, Boyers, Amy, Chadwick, Amy, Telfer, Brian A., Mueller-Klieser, Wolfgang, West, Catharine M., Critchlow, Susan E., Williams, Kaye J., Stratford, Ian J.
Wydane w Sci Rep (2018)

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

od Jones, Dylan T., Valli, Alessandro, Haider, Syed, Zhang, Qifeng, Smethurst, Elizabeth A., Schug, Zachary T., Peck, Barrie, Aboagye, Eric O., Critchlow, Susan E., Schulze, Almut, Gottlieb, Eyal, Wakelam, Michael J.O., Harris, Adrian L.
Wydane w Mol Cancer Ther (2018)

Activity of the Monocarboxylate Transporter 1 inhibitor AZD3965 in Small Cell Lung Cancer

od Polański, Radosław, Hodgkinson, Cassandra L., Fusi, Alberto, Nonaka, Daisuke, Priest, Lynsey, Kelly, Paul, Trapani, Francesca, Bishop, Paul W., White, Anne, Critchlow, Susan E., Smith, Paul D., Blackhall, Fiona, Dive, Caroline, Morrow, Christopher J.
Wydane 2013

Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity

od Curtis, Nicola J., Mooney, Lorraine, Hopcroft, Lorna, Michopoulos, Filippos, Whalley, Nichola, Zhong, Haihong, Murray, Clare, Logie, Armelle, Revill, Mitchell, Byth, Kate F., Benjamin, Amanda D., Firth, Mike A., Green, Stephen, Smith, Paul D., Critchlow, Susan E.
Wydane w Oncotarget (2017)

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

od Noble, Richard A., Bell, Natalie, Blair, Helen, Sikka, Arti, Thomas, Huw, Phillips, Nicole, Nakjang, Sirintra, Miwa, Satomi, Crossland, Rachel, Rand, Vikki, Televantou, Despina, Long, Anna, Keun, Hector C., Bacon, Chris M., Bomken, Simon, Critchlow, Susan E., Wedge, Stephen R.
Wydane w Haematologica (2017)

MCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4

od Hong, Candice Sun, Graham, Nicholas A., Gu, Wen, Camacho, Carolina Espindola, Mah, Vei, Maresh, Erin L., Alavi, Mohammed, Bagryanova, Lora, Krotee, Pascal A. L., Gardner, Brian K., Behbahan, Iman Saramipoor, Horvath, Steve, Chia, David, Mellinghoff, Ingo K., Hurvitz, Sara A., Dubinett, Steven M., Critchlow, Susan E., Kurdistani, Siavash K., Goodglick, Lee, Braas, Daniel, Graeber, Thomas G., Christofk, Heather R.
Wydane w Cell Rep (2016)

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

od Peck, Barrie, Schug, Zachary T., Zhang, Qifeng, Dankworth, Beatrice, Jones, Dylan T., Smethurst, Elizabeth, Patel, Rachana, Mason, Susan, Jiang, Ming, Saunders, Rebecca, Howell, Michael, Mitter, Richard, Spencer-Dene, Bradley, Stamp, Gordon, McGarry, Lynn, James, Daniel, Shanks, Emma, Aboagye, Eric O., Critchlow, Susan E., Leung, Hing Y., Harris, Adrian L., Wakelam, Michael J. O., Gottlieb, Eyal, Schulze, Almut
Wydane w Cancer Metab (2016)

AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo

od Loddick, Sarah A, Ross, Sarah J, Thomason, Andrew G, Robinson, David M, Walker, Graeme E, Dunkley, Tom PJ, Brave, Sandra R, Broadbent, Nicola, Stratton, Natalie C, Trueman, Dawn, Mouchet, Elizabeth, Shaheen, Fadhel S, Jacobs, Vivien N, Cumberbatch, Marie, Wilson, Joanne, Jones, Rhys D O, Bradbury, Robert H, Rabow, Alfred, Gaughan, Luke, Womack, Chris, Barry, Simon T, Robson, Craig N, Critchlow, Susan E, Wedge, Stephen R, Brooks, Nigel A
Wydane 2013

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

od Schug, Zachary T., Peck, Barrie, Jones, Dylan T., Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S., Goodwin, Louise M., Smethurst, Elizabeth, Mason, Susan, Blyth, Karen, McGarry, Lynn, James, Daniel, Shanks, Emma, Kalna, Gabriela, Saunders, Rebecca E., Jiang, Ming, Howell, Michael, Lassailly, Francois, Thin, May Zaw, Spencer-Dene, Bradley, Stamp, Gordon, van den Broek, Niels J.F., Mackay, Gillian, Bulusu, Vinay, Kamphorst, Jurre J., Tardito, Saverio, Strachan, David, Harris, Adrian L., Aboagye, Eric O., Critchlow, Susan E., Wakelam, Michael J.O., Schulze, Almut, Gottlieb, Eyal
Wydane w Cancer Cell (2015)