GRK2 in the Heart: A GPCR Kinase and Beyond

por Huang, Zheng Maggie, Gao, Erhe, Chuprun, J. Kurt, Koch, Walter J.
Publicado 2014

The Evolving Impact of G Protein-Coupled Receptor Kinases in Cardiac Health and Disease

por Sato, Priscila Y., Chuprun, J. Kurt, Schwartz, Mathew, Koch, Walter J.
Publicado en Physiol Rev (2015)

In Vivo Stimulation of α- and β-Adrenoceptors in Mice Differentially Alters Small RNA Content of Circulating Extracellular Vesicles

por Kwon, Jin-Sook, Barr, Eric W., Chuprun, J. Kurt, Koch, Walter J.
Publicado en Cells (2021)

A peptide of the RGS domain of GRK2 binds and inhibits Gα(q) to suppress pathological cardiac hypertrophy and dysfunction

por Schumacher, Sarah M., Gao, Erhe, Cohen, Maya, Lieu, Melissa, Chuprun, J. Kurt, Koch, Walter J.
Publicado en Sci Signal (2016)

GRK5 is a regulator of fibroblast activation and cardiac fibrosis

por Eguchi, Akito, Coleman, Ryan, Gresham, Kenneth, Gao, Erhe, Ibetti, Jessica, Chuprun, J. Kurt, Koch, Walter J.
Publicado en Proc Natl Acad Sci U S A (2021)

GRK2 Compromises Cardiomyocyte Mitochondrial Function by Diminishing Fatty Acid-Mediated Oxygen Consumption and Increasing Superoxide Levels

por Sato, Priscila Y, Chuprun, J Kurt, Ibetti, Jessica, Cannavo, Alessandro, Drosatos, Konstantinos, Elrod, John W, Koch, Walter J
Publicado en J Mol Cell Cardiol (2015)

Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction

por Schumacher, Sarah M., Gao, Erhe, Zhu, Weizhong, Chen, Xiongwen, Chuprun, J. Kurt, Feldman, Arthur M., Tesmer, John J. G., Koch, Walter J.
Publicado en Sci Transl Med (2015)

Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection

por Kwon, Jin-Sook, Schumacher, Sarah M., Gao, Erhe, Chuprun, J. Kurt, Ibetti, Jessica, Roy, Rajika, Khan, Mohsin, Kishore, Raj, Koch, Walter J.
Publicado en Am J Physiol Heart Circ Physiol (2021)

Inhibition of Fas-Associated Death Domain-Containing Protein (FADD) Protects against Myocardial Ischemia/Reperfusion Injury in a Heart Failure Mouse Model

por Fan, Qian, Huang, Zheng M., Boucher, Matthieu, Shang, Xiying, Zuo, Lin, Brinks, Henriette, Lau, Wayne Bond, Zhang, Jianke, Chuprun, J. Kurt, Gao, Erhe
Publicado 2013

Alteration of myocardial GRK2 produces a global metabolic phenotype

por Woodall, Benjamin P., Gresham, Kenneth S., Woodall, Meryl A., Valenti, Mesele-Christina, Cannavo, Alessandro, Pfleger, Jessica, Chuprun, J. Kurt, Drosatos, Konstantinos, Koch, Walter J.
Publicado en JCI Insight (2019)

A Peptide of the Amino-Terminus of GRK2 Induces Hypertrophy and Yet Elicits Cardioprotection after Pressure Overload

por Bledzka, Kamila M., Manaserh, Iyad H., Grondolsky, Jessica, Pfleger, Jessica, Roy, Rajika, Gao, Erhe, Chuprun, J. Kurt, Koch, Walter J., Schumacher, Sarah M.
Publicado en J Mol Cell Cardiol (2021)

Dynamic Changes in Lymphocyte GRK2 Levels in Cardiac Transplant Patients: A Biomarker for Left Ventricular Function

por Bonita, Raphael E., Raake, Philip W., Otis, Nicholas J., Chuprun, J. Kurt, Spivack, Talya, Dasgupta, Abhijit, Whellan, David J., Mather, Paul J., Koch, Walter J.
Publicado 2010

A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse

por Gao, Erhe, Lei, Yong Hong, Shang, Xiying, Huang, Z. Maggie, Zuo, Lin, Boucher, Matthieu, Fan, Qian, Chuprun, J. Kurt, Ma, Xin L., Koch, Walter J.
Publicado 2010

Pro-Death Signaling of GRK2 in Cardiac Myocytes after Ischemic Stress Occurs via ERK-Dependent, Hsp90-Mediated Mitochondrial Targeting

por Chen, Mai, Sat, Priscila Y., Chuprun, J. Kurt, Peroutka, Raymond J., Otis, Nicholas J., Ibetti, Jessica, Pan, Shi, Sheu, Shey-Shing, Gao, Erhe, Koch, Walter J.
Publicado 2013

GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity

por Hullmann, Jonathan E., Grisanti, Laurel A., Makarewich, Catherine A., Gao, Erhe, Gold, Jessica I., Chuprun, J. Kurt, Tilley, Douglass G., Houser, Steven R., Koch, Walter J.
Publicado en Circ Res (2014)

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

por Martini, Jeffrey S., Raake, Philip, Vinge, Leif E., DeGeorge, Brent R., Chuprun, J. Kurt, Harris, David M., Gao, Erhe, Eckhart, Andrea D., Pitcher, Julie A., Koch, Walter J.
Publicado 2008

Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process

por Gold, Jessica I., Martini, Jeffrey S., Hullmann, Jonathan, Gao, Erhe, Chuprun, J. Kurt, Lee, Linda, Tilley, Douglas G., Rabinowitz, Joseph E., Bossuyt, Julie, Bers, Donald M., Koch, Walter J.
Publicado 2013

Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy

por Traynham, Christopher J., Cannavo, Alessandro, Zhou, Yan, Vouga, Alexandre G., Woodall, Benjamin P., Hullmann, Jonathan, Ibetti, Jessica, Gold, Jessica I., Chuprun, J. Kurt, Gao, Erhe, Koch, Walter J.
Publicado en Circ Res (2015)

A peptide of the N-terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure

por Coleman, Ryan C., Eguchi, Akito, Lieu, Melissa, Roy, Rajika, Barr, Eric W., Ibetti, Jessica, Lucchese, Anna-Maria, Peluzzo, Amanda M., Gresham, Kenneth, Chuprun, J. Kurt, Koch, Walter J.
Publicado en Sci Signal (2021)

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity

por Eisner, Verónica, Cupo, Ryan R., Gao, Erhe, Csordás, György, Slovinsky, William S., Paillard, Melanie, Cheng, Lan, Ibetti, Jessica, Chen, S. R. Wayne, Chuprun, J. Kurt, Hoek, Jan B., Koch, Walter J., Hajnóczky, György
Publicado en Proc Natl Acad Sci U S A (2017)