GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity

RATIONALE: G protein-coupled receptor (GPCR) kinases (GRKs) acting in the cardiomyocyte regulate important signaling events that control cardiac function. Both GRK2 and GRK5, the predominant GRKs expressed in the heart, have been shown to be up-regulated in failing human myocardium. While the canoni...

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Publicat a:Circ Res
Autors principals: Hullmann, Jonathan E., Grisanti, Laurel A., Makarewich, Catherine A., Gao, Erhe, Gold, Jessica I., Chuprun, J. Kurt, Tilley, Douglass G., Houser, Steven R., Koch, Walter J.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258119/
https://ncbi.nlm.nih.gov/pubmed/25332207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.304475
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