Pro-Death Signaling of GRK2 in Cardiac Myocytes after Ischemic Stress Occurs via ERK-Dependent, Hsp90-Mediated Mitochondrial Targeting

RATIONALE: GRK2 is abundantly expressed in the heart and its expression and activity is increased in injured or stressed myocardium. This up-regulation has been shown to be pathological. GRK2 can promote cell death in ischemic myocytes and its inhibition by a peptide comprised of the last 194 amino...

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Bibliografski detalji
Glavni autori: Chen, Mai, Sat, Priscila Y., Chuprun, J. Kurt, Peroutka, Raymond J., Otis, Nicholas J., Ibetti, Jessica, Pan, Shi, Sheu, Shey-Shing, Gao, Erhe, Koch, Walter J.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908784/
https://ncbi.nlm.nih.gov/pubmed/23467820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.300754
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