Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation

Increased abundance of GRK2 [G protein–coupled receptor (GPCR) kinase 2] is associated with poor cardiac function in heart failure patients. In animal models, GRK2 contributes to the pathogenesis of heart failure after ischemia-reperfusion (IR) injury. In addition to its role in down-regulating acti...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Sato, Priscila Y., Chuprun, J. Kurt, Grisanti, Laurel A., Woodall, Meryl C., Brown, Brett R., Roy, Rajika, Traynham, Christopher J., Ibetti, Jessica, Lucchese, Anna M., Yuan, Ancai, Drosatos, Konstantinos, Tilley, Doug G., Gao, Erhe, Koch, Walter J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463290/
https://ncbi.nlm.nih.gov/pubmed/30538174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau0144
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