Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation

Increased abundance of GRK2 [G protein–coupled receptor (GPCR) kinase 2] is associated with poor cardiac function in heart failure patients. In animal models, GRK2 contributes to the pathogenesis of heart failure after ischemia-reperfusion (IR) injury. In addition to its role in down-regulating acti...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Sato, Priscila Y., Chuprun, J. Kurt, Grisanti, Laurel A., Woodall, Meryl C., Brown, Brett R., Roy, Rajika, Traynham, Christopher J., Ibetti, Jessica, Lucchese, Anna M., Yuan, Ancai, Drosatos, Konstantinos, Tilley, Doug G., Gao, Erhe, Koch, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463290/
https://ncbi.nlm.nih.gov/pubmed/30538174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau0144
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