Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

G protein-coupled receptor (GPCR) kinases (GRKs) are critical regulators of cellular signaling and function. In cardiomyocytes, GRK2 and GRK5 are two GRKs important for myocardial regulation, and both have been shown to be up-regulated in the dysfunctional heart. We report that increased levels and...

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Detalhes bibliográficos
Main Authors: Martini, Jeffrey S., Raake, Philip, Vinge, Leif E., DeGeorge, Brent R., Chuprun, J. Kurt, Harris, David M., Gao, Erhe, Eckhart, Andrea D., Pitcher, Julie A., Koch, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527933/
https://ncbi.nlm.nih.gov/pubmed/18711143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803153105
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