Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

G protein-coupled receptor (GPCR) kinases (GRKs) are critical regulators of cellular signaling and function. In cardiomyocytes, GRK2 and GRK5 are two GRKs important for myocardial regulation, and both have been shown to be up-regulated in the dysfunctional heart. We report that increased levels and...

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Autores principales: Martini, Jeffrey S., Raake, Philip, Vinge, Leif E., DeGeorge, Brent R., Chuprun, J. Kurt, Harris, David M., Gao, Erhe, Eckhart, Andrea D., Pitcher, Julie A., Koch, Walter J.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2008
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527933/
https://ncbi.nlm.nih.gov/pubmed/18711143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803153105
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