G Protein-Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure

Myocardial G protein-coupled receptor kinase 2 (GRK2) is a critical regulator of cardiac β-adrenergic receptor (βAR) signaling and cardiac function. Its upregulation in heart failure (HF) may further depress cardiac function and contribute to mortality in this syndrome. Preventing GRK2 translocation...

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Main Authors: Raake, Philip W., Vinge, Leif E., Gao, Erhe, Boucher, Matthieu, Chen, Xiongwen, DeGeorge, Brent R., Matkovich, Scot, Houser, Steven R., Most, Patrick, Eckhart, Andrea D., Dorn, Gerald W., Koch, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679955/
https://ncbi.nlm.nih.gov/pubmed/18635825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.107.168336
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