Cardiac GRK2 Ablation Induces a Novel Ca(2+) Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction

BACKGROUND: G-protein coupled receptor kinase 2 (GRK2) is a primary regulator of β-adrenergic signaling in the heart. GRK2 ablation ameliorates heart failure development but the cellular mechanisms have not been elucidated and are the aim of this study. METHODS AND RESULTS: Myocyte contractility, Ca...

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Bibliografiska uppgifter
Huvudupphovsmän: Raake, Philip W., Zhang, Xiaoying, Vinge, Leif E., Brinks, Henriette, Gao, Erhe, Jaleel, Naser, Li, Yingxin, Tang, Mingxin, Most, Patrick, Dorn, Gerald W., Houser, Steven R., Katus, Hugo A., Chen, Xiongwen, Koch, Walter J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908785/
https://ncbi.nlm.nih.gov/pubmed/22496128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.044255
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