Reduction of Sympathetic Activity via Adrenal-targeted GRK2 Gene Deletion Attenuates Heart Failure Progression and Improves Cardiac Function after Myocardial Infarction

Chronic heart failure (HF) is characterized by sympathetic overactivity and enhanced circulating catecholamines (CAs), which significantly increase HF morbidity and mortality. We recently reported that adrenal G protein-coupled receptor kinase 2 (GRK2) is up-regulated in chronic HF, leading to enhan...

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Hlavní autoři: Lymperopoulos, Anastasios, Rengo, Giuseppe, Gao, Erhe, Ebert, Steven N., Dorn, Gerald W., Koch, Walter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871505/
https://ncbi.nlm.nih.gov/pubmed/20351116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077859
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