Reduction of Sympathetic Activity via Adrenal-targeted GRK2 Gene Deletion Attenuates Heart Failure Progression and Improves Cardiac Function after Myocardial Infarction

Chronic heart failure (HF) is characterized by sympathetic overactivity and enhanced circulating catecholamines (CAs), which significantly increase HF morbidity and mortality. We recently reported that adrenal G protein-coupled receptor kinase 2 (GRK2) is up-regulated in chronic HF, leading to enhan...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Lymperopoulos, Anastasios, Rengo, Giuseppe, Gao, Erhe, Ebert, Steven N., Dorn, Gerald W., Koch, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871505/
https://ncbi.nlm.nih.gov/pubmed/20351116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077859
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados