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Inhibition of Angiotensin II Gq Signaling Augments β-Adrenergic Receptor Mediated Effects in a Renal Artery Stenosis Model of High Blood Pressure

Chronic ventricular pressure overload states, such as hypertension, and elevated levels of neurohormones (norepinephrine, angiotensin II, endothelin-1) initiate cardiac hypertrophy and dysfunction and share the property of being able to bind to Gq-coupled 7-transmembrane receptors. The goal of the c...

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Detalhes bibliográficos
Main Authors: Harris, David M., Chen, Xiongwen, Pesant, Stéphanie, Cohn, Heather I., MacDonnell, Scott M., Boucher, Matthieu, Vinge, Leif E., Raake, Philip, Moraca, Susan R., Li, Dongjun, Most, Patrick, Houser, Steven R., Koch, Walter J., Eckhart, Andrea D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633247/
https://ncbi.nlm.nih.gov/pubmed/18930063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2008.09.708
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