Therapeutic potential of KCa3.1 blockers: an overview of recent advances, and promising trends

Por Wulff, Heike, Castle, Neil A.
Publicado em 2010

Voltage-gated Potassium Channels as Therapeutic Drug Targets

Por Wulff, Heike, Castle, Neil A., Pardo, Luis A.
Publicado em 2009

Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation

Por Wang, Lingxin, Zellmer, Shannon G., Printzenhoff, David M., Castle, Neil A.
Publicado no Br J Pharmacol (2015)

Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells

Por Lin, Zhixin, Santos, Sonia, Padilla, Karen, Printzenhoff, David, Castle, Neil A.
Publicado no PLoS One (2016)

PF‐06526290 can both enhance and inhibit conduction through voltage‐gated sodium channels

Por Wang, Lingxin, Zellmer, Shannon G, Printzenhoff, David M, Castle, Neil A
Publicado no Br J Pharmacol (2018)

GI‐530159, a novel, selective, mechanosensitive two‐pore‐domain potassium (K(2P)) channel opener, reduces rat dorsal root ganglion neuron excitability

Por Loucif, Alexandre J C, Saintot, Pierre‐Philippe, Liu, Jia, Antonio, Brett M, Zellmer, Shannon G, Yoger, Katrina, Veale, Emma L, Wilbrey, Anna, Omoto, Kiyoyuki, Cao, Lishuang, Gutteridge, Alex, Castle, Neil A, Stevens, Edward B, Mathie, Alistair
Publicado no Br J Pharmacol (2017)

Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors

Por Sammons, Matthew F., Kharade, Sujay V., Filipski, Kevin J., Boehm, Markus, Smith, Aaron C., Shavnya, Andre, Fernando, Dilinie P., Dowling, Matthew S., Carpino, Philip A., Castle, Neil A., Zellmer, Shannon G., Antonio, Brett M., Gosset, James R., Carlo, Anthony, Denton, Jerod S.
Publicado no ACS Med Chem Lett (2018)

In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K(+) channel opener, A-151892

Por Gopalakrishnan, Murali, Buckner, Steven A, Shieh, Char-Chang, Fey, Thomas, Fabiyi, Adebola, Whiteaker, Kristi L, Davis-Taber, Rachel, Milicic, Ivan, Daza, Anthony V, Scott, Victoria E S, Castle, Neil A, Printzenhoff, David, London, Brecht, Turner, Sean C, Carroll, William A, Sullivan, James P, Coghlan, Michael J, Brune, Michael E
Publicado em 2004

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Por McCormack, Ken, Santos, Sonia, Chapman, Mark L., Krafte, Douglas S., Marron, Brian E., West, Christopher W., Krambis, Michael J., Antonio, Brett M., Zellmer, Shannon G., Printzenhoff, David, Padilla, Karen M., Lin, Zhixin, Wagoner, P. Kay, Swain, Nigel A., Stupple, Paul A., de Groot, Marcel, Butt, Richard P., Castle, Neil A.
Publicado em 2013

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

Por Alexandrou, Aristos J., Brown, Adam R., Chapman, Mark L., Estacion, Mark, Turner, Jamie, Mis, Malgorzata A., Wilbrey, Anna, Payne, Elizabeth C., Gutteridge, Alex, Cox, Peter J., Doyle, Rachel, Printzenhoff, David, Lin, Zhixin, Marron, Brian E., West, Christopher, Swain, Nigel A., Storer, R. Ian, Stupple, Paul A., Castle, Neil A., Hounshell, James A., Rivara, Mirko, Randall, Andrew, Dib-Hajj, Sulayman D., Krafte, Douglas, Waxman, Stephen G., Patel, Manoj K., Butt, Richard P., Stevens, Edward B.
Publicado no PLoS One (2016)