Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors

[Image: see text] Inhibitors of the renal outer medullary potassium channel (ROMK) show promise as novel mechanism diuretics, with potentially lower risk of diuretic-induced hypokalemia relative to current thiazide and loop diuretics. Here, we report the identification of a novel series of 3-sulfamo...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Sammons, Matthew F., Kharade, Sujay V., Filipski, Kevin J., Boehm, Markus, Smith, Aaron C., Shavnya, Andre, Fernando, Dilinie P., Dowling, Matthew S., Carpino, Philip A., Castle, Neil A., Zellmer, Shannon G., Antonio, Brett M., Gosset, James R., Carlo, Anthony, Denton, Jerod S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807870/
https://ncbi.nlm.nih.gov/pubmed/29456800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00481
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