GI‐530159, a novel, selective, mechanosensitive two‐pore‐domain potassium (K(2P)) channel opener, reduces rat dorsal root ganglion neuron excitability

BACKGROUND AND PURPOSE: TREK two‐pore‐domain potassium (K(2P)) channels play a critical role in regulating the excitability of somatosensory nociceptive neurons and are important mediators of pain perception. An understanding of the roles of TREK channels in pain perception and, indeed, in other pat...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Loucif, Alexandre J C, Saintot, Pierre‐Philippe, Liu, Jia, Antonio, Brett M, Zellmer, Shannon G, Yoger, Katrina, Veale, Emma L, Wilbrey, Anna, Omoto, Kiyoyuki, Cao, Lishuang, Gutteridge, Alex, Castle, Neil A, Stevens, Edward B, Mathie, Alistair
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Themed Section: Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980259/
https://ncbi.nlm.nih.gov/pubmed/29150838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14098
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